Entering Week 10 of the NFL season, a lineup of exciting matchups awaits.Colin Cowherd, on Friday, shared his favorite picks for the upcoming weekend.Blazin' 5: Jags upset 49ers, Cowboys embarra s Giants in Colin's Week 10 picks Let's take a closer look.ADVERTISEMENT San Francisco 49ers (-3) @ Jacksonville Jaguars1 p.m. ET, FOXColin's pick, score prediction: DeAndre' Bembry Jersey Jaguars +3 (Jaguars win 27-24)Colin's thoughts: "Can we all just admit Jacksonville is good? They're at home, off a bye, +3. I'm going to take them. They're 2-0 against the weaker NFC this year. is 3-1 against teams with winning records. This is not fools' gold. In the last 17 games, Trevor Lawrence has been everything we were promised out of college: 13-4, 70% completion rate, 100 pa ser rating, six picks."FINAL SF 34 JAX 3 NFL SPREADTO WINTOTAL San Francisco 49ers SF -3.0 -172 O 44.5 Jacksonville Jaguars JAX +3.0 +144 U 44.5 Detroit Lions (-3) @ Los Angeles Chargers4:05 p.m. ET, CBSColin's pick, score prediction: Lions -3 (Lions win 30-24)Colin's thoughts: "We're not getting the C.J. Miles Jersey best number. It was great at -1, but I am still going to take the Lions. I think it's my favorite pick of the week. They're coming off a bye. Offensive coaches off a bye are 3-1 on the road, and their defense, which was the worst in the league, is good this year. They've allowed the fewest big plays in the league. The Chargers don't get big plays anymore. returns and he changes Detroit's offense."FINAL DET 41 LAC 38 NFL SPREADTO WINTOTAL Detroit Lions DET -2.0 -134 O 48 Los Angeles Chargers LAC +2.0 +113 U 48 New York Giants @ Dallas Cowboys (-17)4:25 p.m. ET, FOXColin's pick score prediction: Cowboys -17 (Cowboys win 40-10)Colin's thoughts: "I've never done this. I've never taken a 17-point favorite. But the Cowboys outgained the in Philadelphia by 114 Marcus Camby Jersey yards. is a great home favorite. They're 10-1 off a lo s in the last three years. That's the best in the NFL. I'm taking Dallas. They're also 5-1 against teams under .500."FINAL NYG 17 DAL 49 NFL SPREADTO WINTOTAL New York Giants NYG +17.5 +1121 O 39 Dallas Cowboys DAL -17.5 -2331 U 39 Washington Commanders @ Seattle Seahawks (-6.5)4:25 p.m. ET, FOXColin's pick score prediction Malachi Flynn Jersey : Seahawks -6.5 (Seahawks win 30-20)Colin's thoughts: "Pretend the Baltimore game didn't exist because Baltimore is 17-1 against the NFC. If you have never played , you can't duplicate him in practice. That game doesn't exist. Seattle is really good. They're at home and ticked off. They've been humiliated and won five of their last seven games."FINAL WAS 26 SEA 29 NFL SPREADTO WINTOTAL Washington Commanders WAS +6.0 +212 O 44 Seattle Seahawks SEA -6.0 -262 U 44 Denver Broncos @ Buffalo Bills (-7)Monday 8:15 p.m. ET, ABCColin's pick Malcolm Miller Jersey score prediction: Broncos +7 (Broncos win 27-26)Colin's thoughts: "I don't think Buffalo is very good. They've lost too many good defensive players. I am going to take the Broncos. Extra rest for Sean Payton, four straight games of 100 yards rushing, and playing younger defensive players. They've held opponents under 20 points in three straight games."FINAL DEN 24 BUF 22 NFL SPREADTO WINTOTAL Denver Broncos DEN +7.5 +295 O 47.5 Buffalo Bills BUF -7.5 -377 U 47.5 Follow along with FOX Sports for the latest news on the NFL and other sports.